EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice

@inproceedings{Goldshmit2011EphA4BP,
  title={EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice},
  author={Yona Goldshmit and Mark Damien Spanevello and Sophie Ines Tajouri and Li Li and Fiona Rogers and Martin Pearse and Mary Pauline Galea and Perry F. Bartlett and Andrew W. Boyd and Ann M Turnley},
  booktitle={PloS one},
  year={2011}
}
Upregulation and activation of developmental axon guidance molecules, such as semaphorins and members of the Eph receptor tyrosine kinase family and their ligands, the ephrins, play a role in the inhibition of axonal regeneration following injury to the central nervous system. Previously we have demonstrated in a knockout model that axonal regeneration following spinal cord injury is promoted in the absence of the axon guidance protein EphA4. Antagonism of EphA4 was therefore proposed as a… CONTINUE READING
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