EphA2 expression is associated with aggressive features in ovarian carcinoma.

@article{Thaker2004EphA2EI,
  title={EphA2 expression is associated with aggressive features in ovarian carcinoma.},
  author={Premal H. Thaker and Michael T. Deavers and J. Celestino and Angela Thornton and Mavis S Fletcher and Charles N. Landen and Michael S. Kinch and Peter A. Kiener and Anil Sood},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 15},
  pages={5145-50}
}
PURPOSE EphA2 (epithelial cell kinase) is a transmembrane receptor tyrosine kinase that has been implicated in oncogenesis. There are no published data regarding the role of EphA2 in ovarian carcinoma, which is the focus of the present study. EXPERIMENTAL DESIGN Nontransformed (HIO-180) and ovarian cancer (EG, 222, SKOV3, and A2780-PAR) cell lines were evaluated for EphA2 by Western blot analysis. Five benign ovarian masses, 10 ovarian tumors of low malignant potential, and 79 invasive… CONTINUE READING