EphA kinase activation regulates HGF-induced epithelial branching morphogenesis

  title={EphA kinase activation regulates HGF-induced epithelial branching morphogenesis},
  author={Hui Miao and Christian H. Nickel and Lloyd G. Cantley and Leslie A. Bruggeman and Laura N. Bennardo and Bingcheng Wang},
  journal={The Journal of Cell Biology},
  pages={1281 - 1292}
Eph kinases and their ephrin ligands are widely expressed in epithelial cells in vitro and in vivo. Our results show that activation of endogenous EphA kinases in Madin-Darby canine kidney (MDCK) cells negatively regulates hepatocyte growth factor/scatter factor (HGF)-induced branching morphogenesis in collagen gel. Cotreatment with HGF and ephrin-A1 reduced sprouting of cell protrusions, an early step in branching morphogenesis. Moreover, addition of ephrin-A1 after HGF stimulation resulted in… CONTINUE READING


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  • M. Affolter, S. Bellusci, N. Itoh, B. Shilo, J. P. Thiery, Z. Werb.
  • Remodeling epithelial tissues by branching…
  • 2003
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