EphA 4-Mediated Rho Activation via Vsm-RhoGEF Expressed Specifically in Vascular Smooth Muscle Cells

@inproceedings{Ogita2003EphA4R,
  title={EphA 4-Mediated Rho Activation via Vsm-RhoGEF Expressed Specifically in Vascular Smooth Muscle Cells},
  author={Hisakazu Ogita and Satoshi Kunimoto and Yuji Kamioka and Hirofumi Sawa and Michitaka Masuda and Naoki Mochizuki},
  year={2003}
}
Rho-kinase, an effector of Rho GTPase, increases the contractility of vascular smooth muscle by phosphorylating myosin light chain (MLC) and by inactivating MLC phosphatase. A wide variety of extracellular stimuli activate RhoA via G protein–coupled receptors. In the present study, we demonstrate a novel cell-cell interaction–mediated Rho activation signaling pathway in vascular smooth muscle cells (VSMCs). Among many receptor tyrosine kinases, the Eph family receptors are unique in that they… CONTINUE READING

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