Eph signaling: a structural view.

  title={Eph signaling: a structural view.},
  author={Juha Pekka Himanen and Dimitar B. Nikolov},
  journal={Trends in neurosciences},
  volume={26 1},
Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape and mobility. Both Ephs and ephrins are membrane-bound and their interactions at sites of cell-cell contact initiate unique bidirectional signaling cascades, with information transduced in both the receptor-expressing and the ligand-expressing cells. Recent structural and biophysical studies summarized in this review… CONTINUE READING