Eph receptor tyrosine kinases in tumor and tumor microenvironment.

  title={Eph receptor tyrosine kinases in tumor and tumor microenvironment.},
  author={Dana M. Brantley-Sieders and Sonja I Schmidt and Monica A Parker and Jin Chen},
  journal={Current pharmaceutical design},
  volume={10 27},
Eph receptors are a unique family of receptor tyrosine kinases (RTK) that play critical roles in embryonic patterning, neuronal targeting, and vascular development during embryogenesis. In adults, Eph RTKs and their ligands, the ephrins, are frequently overexpressed in a variety of cancers and tumor cell lines, including breast, prostate, non-small cell lung and colon cancers, melanomas, and neuroblastomas. Unlike traditional oncogenes that often function only in tumor cells, recent data show… CONTINUE READING
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