Eph receptor–ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro

@article{Ciossek1998EphRI,
  title={Eph receptor–ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro},
  author={Thomas Ciossek and Bruno Monschau and Claus Kremoser and J{\"u}rgen L{\"o}schinger and Susanne B. Lang and Bernhard K. M{\"u}ller and Friedrich Bonhoeffer and Uwe Drescher},
  journal={European Journal of Neuroscience},
  year={1998},
  volume={10}
}
Previous results of an in vitro guidance test, the stripe assay, have demonstrated the presence of a repulsive axon guidance activity for temporal retinal axons in the posterior part of the vertebrate optic tectum. Ephrin‐A5 and Ephrin‐A2 are ligands for the EphA subfamily of Eph receptor tyrosine kinases, which are expressed in overlapping gradients in the posterior part of the tectum. When recombinantly expressed, both proteins have been shown to guide retinal ganglion cell axons in the… 
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TLDR
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Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain.
TLDR
A conserved function for EphA receptors and their ligands in the elaboration of topographic maps at multiple levels of the visual pathway is suggested.
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TLDR
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TLDR
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TLDR
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TLDR
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