Eph receptor–ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro

@article{Ciossek1998EphRI,
  title={Eph receptor–ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro},
  author={Thomas Ciossek and Bruno Monschau and Claus Kremoser and J{\"u}rgen L{\"o}schinger and Susanne B. Lang and Bernhard K. M{\"u}ller and Friedrich Bonhoeffer and Uwe Drescher},
  journal={European Journal of Neuroscience},
  year={1998},
  volume={10}
}
Previous results of an in vitro guidance test, the stripe assay, have demonstrated the presence of a repulsive axon guidance activity for temporal retinal axons in the posterior part of the vertebrate optic tectum. Ephrin‐A5 and Ephrin‐A2 are ligands for the EphA subfamily of Eph receptor tyrosine kinases, which are expressed in overlapping gradients in the posterior part of the tectum. When recombinantly expressed, both proteins have been shown to guide retinal ganglion cell axons in the… 
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On the turning of Xenopus retinal axons induced by ephrin-A5
TLDR
Ephrin-As are able to guide axons in immobilised bound form as well as in the form of soluble molecules, indicating that this type of guidance is relevant for the in vivo situation.
Modulation of EphA Receptor Function by Coexpressed EphrinA Ligands on Retinal Ganglion Cell Axons
Ephrin-A6, a new ligand for EphA receptors in the developing visual system.
TLDR
The asymmetric distribution of ephrin-A6 in retinal cells, and the time course of its expression, suggest that this new Ephrin plays a role in the establishment of visual system topography.
The EphA4 Receptor Tyrosine Kinase Is Necessary for the Guidance of Nasal Retinal Ganglion Cell Axons in Vitro
TLDR
The results of these in vitro experiments suggest that EphA4 is crucially involved in the repulsive guidance of nasal but not of temporal axons, suggesting the role of one of the multiple Eph a receptors expressed on retinal ganglion cell axons is investigated.
Src Family Kinases Are Involved in EphA Receptor-Mediated Retinal Axon Guidance
TLDR
The data suggest an important role of SFKs as downstream signaling molecules in EphA receptor-mediated repulsive axon guidance in the retinotectal projection.
EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression
Eph receptors and ephrins: regulators of guidance and assembly.
Expression of EphA4, Ephrin-A2 and Ephrin-A5 during Axon Outgrowth to the Hindlimb Indicates Potential Roles in Pathfinding
TLDR
The results suggest that EphA4 RTK and its ligands may influence axon fasciculation and the sorting of axons at the limb plexus, contributing to the correct dorsoventral organization of nerve branches in the hindlimb.
Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons.
TLDR
It is shown that overexpression of ephrinA5 affects the topographic targeting behavior of both temporal and nasal axons, and this data reinforce the idea that differential ligand expression on retinal axons contributes to topography targeting in the retinotectal projection.
Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain.
TLDR
A conserved function for EphA receptors and their ligands in the elaboration of topographic maps at multiple levels of the visual pathway is suggested.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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