Eph-modulated cell morphology, adhesion and motility in carcinogenesis.

  title={Eph-modulated cell morphology, adhesion and motility in carcinogenesis.},
  author={Sabine H. Wimmer-Kleikamp and Martin Lackmann},
  journal={IUBMB life},
  volume={57 6},
Eph receptor tyrosine kinases (Ephs) and their membrane anchored ephrin ligands (ephrins) form an essential cell-cell communication system that directs the positioning, adhesion and migration of cells and cell layers during development. While less prominent in normal adult tissues, there is evidence that up-regulated expression and de-regulated function of Ephs and ephrins in a large variety of human cancers may promote a more aggressive and metastatic tumour phenotype. However, in contrast to… CONTINUE READING


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