Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes.

@article{Walsh2012Eph2BAA,
  title={Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes.},
  author={Rebecca Walsh and M Blumenberg},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 6},
  pages={2330-40}
}
In the bi-directional signaling system comprising ephrins (EFNs) and ephrin receptors (Ephs), both EFNs and Ephs simultaneously function both as ligands and as receptors. Importantly, the EFN/Eph system is deregulated in human cancers and has been implicated in the metastatic processes because of its effects on the adhesion and migration of epithelial cells. The idiosyncratic function of Ephs, membrane-bound receptor kinases, as extracellular signaling ligands, has not been extensively studied… CONTINUE READING