Epac2-mediated dendritic spine remodeling: implications for disease.

  title={Epac2-mediated dendritic spine remodeling: implications for disease.},
  author={Peter Penzes and Kevin M. Woolfrey and Deepak P Srivastava},
  journal={Molecular and cellular neurosciences},
  volume={46 2},
In the mammalian forebrain, most glutamatergic excitatory synapses occur on small dendritic protrusions called dendritic spines. Dendritic spines are highly plastic and can rapidly change morphology in response to numerous stimuli. This dynamic remodeling of dendritic spines is thought to be critical for information processing, memory and cognition. Conversely, multiple studies have revealed that neuropathologies such as autism spectrum disorders (ASDs) are linked with alterations in dendritic… CONTINUE READING


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