Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells

@inproceedings{Seo2016Epac2CT,
  title={Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells},
  author={Hyunhyo Seo and Kyungmin Lee},
  booktitle={BMB reports},
  year={2016}
}
Astrocytes play a critical role in normal brain functions and maintaining the brain microenvironment, and defects in astrocytogenesis during neurodevelopment could give rise to severe mental illness and psychiatric disorders. During neuro-embryogenesis, astrocytogenesis involves astrocytic differentiation of neural precursor cells (NPCs) induced by signals from ciliary neurotrophic factor (CNTF) or pituitary adenylate cyclase-activating peptide (PACAP). However, in contrast to the CNTF… CONTINUE READING

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