Epac1-mediated, high glucose-induced renal proximal tubular cells hypertrophy via the Akt/p21 pathway.

@article{Sun2011Epac1mediatedHG,
  title={Epac1-mediated, high glucose-induced renal proximal tubular cells hypertrophy via the Akt/p21 pathway.},
  author={Lin Sun and Vinay K Kondeti and Ping Xie and Kirtee Raparia and Yashpal S. Kanwar},
  journal={The American journal of pathology},
  year={2011},
  volume={179 4},
  pages={1706-18}
}
The mechanisms involved in tubular hypertrophy in diabetic nephropathy are unclear. We investigated the role of exchange protein activated by cAMP 1(Epac1), which activates Rap-family G proteins in cellular hypertrophy. Epac1 is expressed in heart, renal tubules, and in the HK-2 cell line. In diabetic mice, increased Epac1 expression was observed, and under… CONTINUE READING