Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.

@article{Yokoyama2008Epac1IU,
  title={Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.},
  author={Utako Yokoyama and Susumu Minamisawa and Hong Quan and Toru Akaike and Meihua Jin and Koji Otsu and Coskun Ulucan and Xu Wang and Erdenechimeg Baljinnyam and Minoru Takaoka and Masataka Sata and Yoshihiro Ishikawa},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 4},
  pages={H1547-55}
}
Vascular remodeling after mechanoinjury largely depends on the migration of smooth muscle cells, an initial key step to wound healing. However, the role of the second messenger system, in particular, the cAMP signal, in regulating such remodeling remains controversial. Exchange protein activated by cAMP (Epac) has been identified as a new target molecule of the cAMP signal, which is independent from PKA. We thus examined whether Epac plays a distinct role from PKA in vascular remodeling. To… CONTINUE READING
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