EpIC: a rational pipeline for epitope immunogenicity characterization

  title={EpIC: a rational pipeline for epitope immunogenicity characterization},
  author={Kristen Marciniuk and Brett Trost and Scott Napper},
  volume={31 14},
UNLABELLED Efforts to develop peptide-based vaccines, in particular those requiring site-specific targeting of self-proteins, rely on the ability to optimize the immunogenicity of the peptide epitopes. Currently, screening of candidate vaccines is typically performed through low-throughput, high-cost animal trials. To improve on this we present the program EpIC, which enables high-throughput prediction of peptide immunogenicity based on the endogenous occurrence of B-cell epitopes within native… CONTINUE READING
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