EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

@inproceedings{Subramanian2014EpCAMAM,
  title={EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex},
  author={Nithya Subramanian and J. R. Kanwar and Prasanna kumar Athalya and Narayanan Janakiraman and Vikas Khetan and Rupinder Kaur Kanwar and Sailaja Eluchuri and Subramanium Krishnakumar},
  booktitle={Journal of Biomedical Science},
  year={2014}
}
Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, efficiently inhibits cancer cell proliferation. Targeted delivery of siRNA using polyethyleneimine is one of the efficient methods for gene delivery, and thus, we developed a novel aptamer-PEI-siRNA nanocomplex for… CONTINUE READING

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Novel epithelial cell adhesion molecule antibody conjugated Subramanian et al

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