EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.

@article{Yamashita2008EpCAMAA,
  title={EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.},
  author={Taro Yamashita and Marshonna Forgues and Wei Wang and Jin Woo Kim and Qinghai Ye and Huliang Jia and Anuradha S. Budhu and Krista A. Zanetti and Yidong Chen and Lunxiu Qin and Zhao-you Tang and Xin Wei Wang},
  journal={Cancer research},
  year={2008},
  volume={68 5},
  pages={
          1451-61
        }
}
The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in premalignant hepatic tissues and in a subset of HCC. In this study, we aimed to identify novel HCC subtypes that resemble certain stages of liver… CONTINUE READING
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