Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.

@article{Rothenberg1996EotaxinTE,
  title={Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.},
  author={Marc E Rothenberg and Robert T. Ownbey and Paul D Mehlhop and Paul Loiselle and Matt van de Rijn and Joseph V. Bonventre and Hans C. Oettgen and Philip Leder and Andrew D Luster},
  journal={Molecular medicine},
  year={1996},
  volume={2 3},
  pages={
          334-48
        }
}
BACKGROUND Understanding the processes that control selective eosinophilia is of fundamental importance in a variety of human diseases (e.g., allergies, parasitic infections, malignancy). Interleukin 5, an eosinophil-specific growth and activating factor, and eotaxin appear to collaborate in this process. Eotaxin is a recently described chemotactic factor that belongs to the C-C (or beta) chemokine family and has been implicated in animal and human eosinophilic inflammatory states. We have… CONTINUE READING

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