Eotaxin polymorphisms and serum total IgE levels in children with asthma.

  title={Eotaxin polymorphisms and serum total IgE levels in children with asthma.},
  author={Benjamin A. Raby and Kristel van Steen and Ross Lazarus and Juan C Celed{\'o}n and Edwin K. Silverman and Scott T. Weiss},
  journal={The Journal of allergy and clinical immunology},
  volume={117 2},
BACKGROUND Eotaxin (chemokine, CC motif, ligand; CCL11) is a potent eosinophil chemoattractant strongly implicated in the pathobiology of asthma. Genetic variation at the CCL11 locus has been correlated with serum total IgE, blood eosinophil counts, and circulating eotaxin protein levels in several case-control asthma studies. Family-based association studies of CCL11 genetic variants have not been reported to date. OBJECTIVE To evaluate 9 common CCL11 single nucleotide polymorphisms (SNPs… CONTINUE READING


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