Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.

@article{Ogilvie2001EotaxinIA,
  title={Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.},
  author={Patricia Ogilvie and Giuseppe Bardi and I Clark-lewis and Marco Baggiolini and Mariagrazia Uguccioni},
  journal={Blood},
  year={2001},
  volume={97 7},
  pages={
          1920-4
        }
}
Eotaxin is a potent inducer of eosinophil chemotaxis and was considered as a selective ligand of the CC chemokine receptor 3 (CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. This study shows that eotaxin also interacts with CCR2 and CCR5 and can, thus, affect the responses of monocytes, which express both receptors. In human monocytes pretreatment with eotaxin decreased responsiveness to MCP-1, a selective ligand for CCR2, as well as to RANTES and MIP-1 beta, which… CONTINUE READING

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