Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma

  title={Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma},
  author={R. V. M. S. S. Kiran Kumar and Paul Thomas and D q Seetoo and Cristan Herbert and Andrew N. J. McKenzie and Paul S Foster and Andrew R. Lloyd},
  journal={Laboratory Investigation},
Chemoattractants such as eotaxin are believed to play an important role in the recruitment of eosinophils into the airways in asthma. We investigated expression of eotaxin in the airway wall in a model of chronic human asthma, in which systemically sensitized mice were exposed to low mass concentrations of aerosolized antigen for 6 weeks. In these animals, the number of intraepithelial eosinophils in the airways was significantly increased 3 hours after exposure and declined by 24 hours. In… CONTINUE READING

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Effects of an interleukin - 5 blocking monoclonal antibody on eosinophils , airway hyper - responsiveness , and the late asthmatic response

  • L Li, Y Xia, +4 authors D Lo
  • Lancet
  • 1999
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