Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.

@article{Schuh2002EotaxinCCL11II,
  title={Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.},
  author={Jane M. Schuh and Kate Blease and Steven L. Kunkel and Cory M Hogaboam},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 1},
  pages={L198-204}
}
Eotaxin/CCL11 is a major chemoattractant for eosinophils and Th2 cells. As such, it represents an attractive target in the treatment of allergic disease. The present study addresses the role of eotaxin/CCL11 during acute and chronic allergic airway responses to the fungus Aspergillus fumigatus. Mice lacking the eotaxin gene (Eo-/-) and wild-type mice (Eo+/+) were sensitized to A. fumigatus and received either an intratracheal challenge with soluble A. fumigatus antigens (acute model) or an… CONTINUE READING