Eosinophils preferentially use bromide to generate halogenating agents.

  title={Eosinophils preferentially use bromide to generate halogenating agents.},
  author={A N Mayeno and Aongus James Curran and Robert Edmund Roberts and Christopher S. Foote},
  journal={The Journal of biological chemistry},
  volume={264 10},
Human eosinophils preferentially utilize bromide to generate a brominating agent, even at physiological halide concentrations, where chloride (140 mM) is over 1000-fold greater than bromide (20-100 microM). Under the same conditions, neutrophils use chloride to generate a chlorinating agent. The total amount of active halogen trapped by 1,3,5-trimethoxybenzene from eosinophils increases by over 2-fold as the added bromide concentration increases from 0 to 100 microM, with approximately 40 nmol… CONTINUE READING