Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus.

@article{Phipps2007EosinophilsCT,
  title={Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus.},
  author={Simon Phipps and Chuan En Lam and Suresh Mahalingam and Matthew Newhouse and Ruben Garcia Ramirez and H F Rosenberg and Paul S Foster and Klaus Ingo Matthaei},
  journal={Blood},
  year={2007},
  volume={110 5},
  pages={1578-86}
}
Eosinophils are recruited to the lungs in response to respiratory syncytial virus (RSV) infection; however, their role in promoting antiviral host defense remains unclear. Here, we demonstrate that eosinophils express TLRs that recognize viral nucleic acids, are activated and degranulate after single-stranded RNA (ssRNA) stimulation of the TLR-7-MyD88 pathway, and provide host defense against RSV that is MyD88 dependent. In contrast to wild-type mice, virus clearance from lung tissue was more… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

temic eosinophil response induced by respiratory syncytial virus

  • H Hemmi, T Kaisho, K Takeda, S Akira
  • Clin Exp Immunol
  • 2006

Asth - matic bronchial epithelial cells have a deficient innate immune response to infection with rhinovi

  • F Bucchieri
  • J Exp Med
  • 2005

Similar Papers

Loading similar papers…