Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease.


Aspirin-exacerbated respiratory disease (AERD) involves overexpression of proinflammatory mediators, including 5-lipoxygenase and leukotriene C4 synthase (LTC4S), resulting in constitutive overproduction of cysteinyl leukotrienes. Mast cells and eosinophils have roles in mediating many of the observed effects. Increased levels of both interleukin-4 (IL-4… (More)
DOI: 10.1016/j.iac.2016.06.008


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