Eosinophils: from low‐ to high‐affinity immunoglobulin E receptors

@article{Capron1995EosinophilsFL,
  title={Eosinophils: from low‐ to high‐affinity immunoglobulin E receptors},
  author={M. Capron and Abdelillah Soussi Gounni and Minoru Morita and Marie Jos{\'e} Truong and Lionel Prin and Jean Pierre Kinet and Andr{\'e} Capron},
  journal={Allergy},
  year={1995},
  volume={50}
}
Several experimental approaches have been used to identify immunoglobulin (IgE) binding molecules expressed by human eosinophils. After the description that Fee RII/CD23 identified on eosinophils could participate in IgE binding and IgE‐mediated cytotoxicity, Mac2/ε binding proteins belonging to the S‐type lectin family were also detected on human eosinophits. Anti‐Mac2 monoclonal antibodies inhibited eosinophil‐dependent cytotoxicity towards parasitic targets. More recently, Fcε RI was… 
Hemopoietic progenitors and cytokines in allergic inflammation
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The contribution of the bone marrow to allergic inflammation is highlighted by summarizing a body of work which has accumulated demonstrating the active upregulation, release, and recruitment of eosinophil-basophil progenitors (CFU-EolB) to tissue sites in response to allergen provocation or during exacerbations of allergic inflammatory diseases.
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To the Editor: The expression of receptors for IgE on human eosinophils remains controversial, as reviewed in a recent comprehensive editorial.[1][1] Although human eosinophils from subjects
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Eosinophils: Biological Properties and Role in Health and Disease
  • S. Hogan, H. Rosenberg, M. Rothenberg
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2008
TLDR
The biology of eosinophils is summarized, focusing on transcriptional regulation of eOSinophil differentiation, characterization of the growing properties of eOsinophIL granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of Eosinophile degranulation.
The cells of the allergic response: mast cells, basophils, and eosinophils.
TLDR
Evidence shows that mast cells, basophils, and eosinophils can secrete a wide spectrum of cytokines and, in some cases, express functions that may permit them to regulate the development or perpetuation of allergic responses.
CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness.
TLDR
Absence of CD23 in gene-deficient mice significantly enhanced OA-specific IgE and IgG(1) levels, airway eosinophilia, and AHR when compared with CD23+/+ wild-type littermates after sensitization and airway challenge, demonstrating a limiting role ofCD23 in the development of allergic AHR.
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