Eosinophilic Granulomatosis with Polyangiitis (Churg‐Strauss)

@article{Nguyen2018EosinophilicGW,
  title={Eosinophilic Granulomatosis with Polyangiitis (Churg‐Strauss)},
  author={Yann Nguyen and Lo{\"i}c Guillevin},
  journal={Seminars in Respiratory and Critical Care Medicine},
  year={2018},
  volume={39},
  pages={471–481}
}
&NA; Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg‐Strauss syndrome, is a systemic necrotizing vasculitis of small‐ and medium‐size vessels, characterized by asthma and blood eosinophilia. EGPA typically occurs in patients with preexisting asthma, and involves the skin, lungs, and peripheral nerves. Poor‐prognosis factors (i.e., involvement(s) of the gastrointestinal tract, heart, and/or kidney) have been assessed with the Five‐Factor Score (FFS). One‐third of the… Expand
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54 Citations
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Background Citations
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54 Citations

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Eosinophilic Granulomatosis with Polyangiitis: Experiences in Korean Patients
TLDR
The classification criteria for EGPA is described and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGpa are described. Expand
Churg Strauss Syndrome
Churg Straus Syndrome – renamed as eosinophilic granulomatosis with polyangiitis (EGPA) – is a specific variant of the group of diseases characterized by necrotizing vasculitis of small and… Expand
Treatment of Eosinophilic Granulomatosis with Polyangiitis: A Review
TLDR
Characteristics of eosinophilic granulomatosis with polyangiitis are reviewed and an overview of established and novel pharmacological agents is provided. Expand
Mepolizumab for the treatment of eosinophilic granulomatosis with polyangiitis
TLDR
The available literature supports the use of mepolizumab for the induction and maintenance of remission of refractory, relapsing, or glucocorticoid-dependent EGPA with potentially greater benefit in those who are ANCA-positive or those with greater eosinophilia (150 cells/L). Expand
Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.
TLDR
This review synthesizes knowledge of the pathogenesis of EGPA and attempts to distinguish EGPA from other diseases including other AAVs, asthma, allergy and hypereosinophilic-associated conditions and speculate about the preponderant mechanisms, which could explain the two disease phenotypes. Expand
Granulomatosis with polyangiitis presenting with pachymeningitis and persistent headache
TLDR
A case of granulomatosis with polyangiitis in a patient with persistent frontal headache, for a very long time considered as migraine versus tension-type headache is reported. Expand
Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)
TLDR
In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long- term management and morbidity. Expand
Granulomatosis eosinofílica con poliangitis: reporte de un caso y revisión de la literatura
TLDR
The case of a 13 year old boy with diffi cult to control asthma and impaired general condition, which was fi nally diagnosed with EGPA, ANCA-negative, is reported. Expand
Lung involvement in ANCA-associated vasculitis.
TLDR
Questions remain, including local treatments for subglottic stenosis, the uncertain efficacy of plasma exchanges for alveolar hemorrhage, the potential role of antifibrotic agents in ILD associated with MPA, and the use of novel anti-IL-5 strategies in EGPA are discussed. Expand
Multiple strokes and cerebral microangiopathy in a patient with Churg-Strauss syndrome
TLDR
The case of a 79-year-old woman diagnosed in 2016 with EGPA, being treated with Prednisone and Azathioprine, who presented to the Neurological Emergency Department with right hemiplegia, dysmetria in the left arm and right hemi-hypoesthesia is presented. Expand
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References

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TLDR
The treatment of EGPA with rituximab resulted in high rates of improvement and reduced requirement of prednisolone, and may be considered for the treatment ofEGPA. Expand
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Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)
TLDR
In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long- term management and morbidity. Expand
Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases.
TLDR
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TLDR
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TLDR
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Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort.
TLDR
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