Eosinophilic Granulomatosis with Polyangiitis (Churg‐Strauss)

@article{Nguyen2018EosinophilicGW,
  title={Eosinophilic Granulomatosis with Polyangiitis (Churg‐Strauss)},
  author={Yann Nguyen and Lo{\"i}c Guillevin},
  journal={Seminars in Respiratory and Critical Care Medicine},
  year={2018},
  volume={39},
  pages={471–481}
}
&NA; Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg‐Strauss syndrome, is a systemic necrotizing vasculitis of small‐ and medium‐size vessels, characterized by asthma and blood eosinophilia. EGPA typically occurs in patients with preexisting asthma, and involves the skin, lungs, and peripheral nerves. Poor‐prognosis factors (i.e., involvement(s) of the gastrointestinal tract, heart, and/or kidney) have been assessed with the Five‐Factor Score (FFS). One‐third of the… 
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62 Citations

Eosinophilic Granulomatosis with Polyangiitis: Experiences in Korean Patients
TLDR
The classification criteria for EGPA is described and recommendations for the evaluation and management of EGPA with conventional and newly suggested drugs for EGpa are described.
Eosinophilic granulomatosis with polyangiitis: modern view on pathogenesis and treatment (literature review)
TLDR
Clinical manifestations in EGPA tend to divide patients into two subset of the disease, with a predominance of vasculitic or eosinophilic manifestations, and ANCA can differentiate between these two subsets, but there is no insufficient understanding to use phenotype2tailored therapies.
Churg Strauss Syndrome
Churg Straus Syndrome – renamed as eosinophilic granulomatosis with polyangiitis (EGPA) – is a specific variant of the group of diseases characterized by necrotizing vasculitis of small and…
Treatment of Eosinophilic Granulomatosis with Polyangiitis: A Review
TLDR
Characteristics of eosinophilic granulomatosis with polyangiitis are reviewed and an overview of established and novel pharmacological agents is provided.
Eosinophilic granulomatosis with polyangiitis as a rare cause of the syndrome of inappropriate antidiuretic hormone secretion
TLDR
A rare case of syndrome of the inappropriate antidiuretic hormone (ADH) secretion (SIadH) secondary to EGPA is reported, which implies a causality between two conditions.
Mepolizumab for the treatment of eosinophilic granulomatosis with polyangiitis
TLDR
The available literature supports the use of mepolizumab for the induction and maintenance of remission of refractory, relapsing, or glucocorticoid-dependent EGPA with potentially greater benefit in those who are ANCA-positive or those with greater eosinophilia (150 cells/L).
Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.
Granulomatosis with polyangiitis presenting with pachymeningitis and persistent headache
TLDR
A case of granulomatosis with polyangiitis in a patient with persistent frontal headache, for a very long time considered as migraine versus tension-type headache is reported.
Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)
TLDR
In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long- term management and morbidity.
Granulomatosis eosinofílica con poliangitis: reporte de un caso y revisión de la literatura
TLDR
The case of a 13 year old boy with diffi cult to control asthma and impaired general condition, which was fi nally diagnosed with EGPA, ANCA-negative, is reported.
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References

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Drawing on our experience of 16 cases and a review of the English literature, we propose that CSS is under-diagnosed because of exclusive emphasis upon pathologic recognition of the disorder. The…
Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg–Strauss)
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TLDR
In EGPA, asthma is severe, antedates systemic manifestations by a mean of 12 years, and progresses to long-term persistent airflow obstruction despite corticosteroids in a large proportion of patients, which affects long- term management and morbidity.
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TLDR
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TLDR
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TLDR
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TLDR
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