Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.

@article{Eum1995EosinophilRI,
  title={Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.},
  author={S Y Eum and Saba Haile and J. -M. Lefort and Michel Ren{\'e} Huerre and Bernardo Boris Vargaftig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 26},
  pages={12290-4}
}
A murine model for antigen-induced bronchial hyperreactivity (BHR) and airway eosinophilia, two hallmarks of asthma, was developed using ovalbumin-immunized mice, which produce large amounts of IgE (named BP2, "Bons Producteurs 2," for High Line of Selection 2). A single intranasal ovalbumin challenge failed to modify the bronchial responses, despite the intense eosinophil recruitment into the bronchoalveolar lavage fluid and airways. When mice were challenged twice a day for 2 days or once a… CONTINUE READING