Eosinophil peroxidase-induced mast cell secretion

  title={Eosinophil peroxidase-induced mast cell secretion},
  author={William Reed Henderson and Emil Y. Chi and Seymour J. Klebanoff},
  journal={The Journal of Experimental Medicine},
  pages={265 - 279}
Eosinophil peroxidase (EPO) at relatively low levels (4-30 mU), when supplemented with H2O2 and a halide, induced mast cell degranulation. Histamine release occurred without concomitant release of the cytoplasmic marker lactic dehydrogenase (LDH), and this, together with ultrastructural studies, indicated a noncytotoxic effect comparable with that induced by other mast cell secretagogues. At pH 7.4, iodide was effective at concentrations down to 10(-5) M, and although chloride alone was… CONTINUE READING
39 Citations
1 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 39 extracted citations


Publications referenced by this paper.

Similar Papers

Loading similar papers…