Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4.

@article{Bruijnzeel1993EosinophilMI,
  title={Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4.},
  author={Piet L. B. Bruijnzeel and Philip H M Kuijper and Silvia Rihs and Steve Betz and R. A. J. Warringa and Leo Koenderman},
  journal={The Journal of investigative dermatology},
  year={1993},
  volume={100 2},
  pages={137-42}
}
Eosinophil granular protein deposits have been demonstrated in lesional atopic dermatitis skin. This suggests active tissue infiltration of eosinophils. To find an explanation for the tissue influx of eosinophils, eosinophil migration was studied in vitro by means of a microchemotaxis assay. Eosinophils from the circulation of patients with atopic dermatitis showed an altered capacity to respond to chemotactic stimuli in vitro compared with eosinophils from healthy donors. Eosinophils from… CONTINUE READING