Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.

@article{Bruin2010EosinophilDI,
  title={Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.},
  author={Alexander M de Bruin and M. D. J. Buitenhuis and Koenraad F. van der Sluijs and Klaas P J M van Gisbergen and Louis Boon and Martijn A Nolte},
  journal={Blood},
  year={2010},
  volume={116 14},
  pages={
          2559-69
        }
}
To explore whether and how T cells can affect myelopoiesis, we investigated myeloid differentiation in a model for T cell-mediated immune activation. We found that CD70-transgenic (CD70TG) mice, which have elevated numbers of interferon-γ (IFN-γ)-producing effector T cells in the periphery and bone marrow, are almost devoid of eosinophilic granulocytes. Induction of allergic airway inflammation in these mice failed to induce eosinophilia as well as airway hyperresponsiveness. CD70TG mice also… CONTINUE READING

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