Eosinophil development and bone marrow and tissue eosinophils in atopic asthma.

@article{Robinson1999EosinophilDA,
  title={Eosinophil development and bone marrow and tissue eosinophils in atopic asthma.},
  author={D Robinson and Janet M North and Kyriaki Zeibecoglou and Sun Ying and Qiu Meng and Scott Rankin and Qutayba A Hamid and Jan Tavernier and Antony B. Kay},
  journal={International archives of allergy and immunology},
  year={1999},
  volume={118 2-4},
  pages={98-100}
}
BACKGROUND Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmatic and control subjects for expression of the eotaxin receptor, CCR3. RESULTS Acquisition of receptors for IL-5 and CCR3 was an early event in eosinophil development. There… CONTINUE READING

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