Eosinophil Cationic Protein Stimulates TGF-β1 Release by Human Lung Fibroblasts In Vitro

@article{Zagai2007EosinophilCP,
  title={Eosinophil Cationic Protein Stimulates TGF-β1 Release by Human Lung Fibroblasts In Vitro},
  author={Ulrika Zagai and Elham Dadfar and J. U. E. Lundahl and Per Venge and Carl Magnus Sk{\"o}ld},
  journal={Inflammation},
  year={2007},
  volume={30},
  pages={153-160}
}
Eosinophilic inflammation and airway remodeling are features of asthma. Eosinophil cationic protein (ECP) is released by activated eosinophils and transforming growth factor (TGF)-β1 has major functions in the fibrotic process. We therefore hypothesized that ECP stimulates TGF-β1 release by human lung fibroblasts. Fibroblasts in monolayer displayed a constitutive release of TGF-β1, which increased in presence of ECP (436 ± 60 vs. 365 ± 48 pg/ml at 48 h; P < 0.01). mRNA expression of TGF-β1 was… CONTINUE READING