Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.

@article{Rieder2015EosIR,
  title={Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.},
  author={Sadiye Amcaoglu Rieder and Amina Metidji and Deborah D Glass and Angela M Thornton and Tohru Ikeda and Bruce Morgan and Ethan M Shevach},
  journal={Journal of immunology},
  year={2015},
  volume={195 2},
  pages={
          553-63
        }
}
Eos belongs to the Ikaros family of transcription factors. It was reported to be a regulatory T cell (Treg) signature gene, to play a critical role in Treg suppressor functions, and to maintain Treg stability. We used mice with a global deficiency in Eos to re-examine the role of Eos expression in both Tregs and conventional T cells (Tconvs). Tregs from Eos-deficient (Eos(-/-)) mice developed normally, displayed a normal Treg phenotype, and exhibited normal suppressor function in vitro. Eos… CONTINUE READING
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