Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines.

@article{Fukuoka2016EomesoderminPI,
  title={Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines.},
  author={Natsuki Fukuoka and Misuzu Harada and Ai Nishida and Yuko Ito and Hideki Shiota and Takao Kataoka},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2016},
  volume={21 2},
  pages={146-62}
}
The T-box transcription factors T-bet and eomesodermin (Eomes) have been shown to regulate the lineage-specific expression of interferon-γ (IFN-γ). However, in contrast to T-bet, the role of Eomes in the expression of IFN-γ remains unclear. In this study, we investigated the Eomes-dependent expression of IFN-γ in the mouse thymoma BW5147 and EL4 cells, which do not express T-bet or Eomes. The ectopic expression of Eomes induced BW5147 and EL4 cells to produce IFN-γ in response to phorbol 12… CONTINUE READING
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