Enzymology of the repair of free radicals-induced DNA damage

@article{Gros2002EnzymologyOT,
  title={Enzymology of the repair of free radicals-induced DNA damage},
  author={Laurent Gros and Murat K Saparbaev and J. Laval},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={8905-8925}
}
A number of intrinsic and extrinsic mutagens induce structural damage in cellular DNA. These DNA damages are cytotoxic, miscoding or both and are believed to be at the origin of cell lethality, tissue degeneration, ageing and cancer. In order to counteract immediately the deleterious effects of such lesions, leading to genomic instability, cells have evolved a number of DNA repair mechanisms including the direct reversal of the lesion, sanitation of the dNTPs pools, mismatch repair and several… CONTINUE READING

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