Enzymology of mitochondrial base excision repair.

  title={Enzymology of mitochondrial base excision repair.},
  author={Daniel F. Bogenhagen and Kevin G Pinz and R M Perez-Jannotti},
  journal={Progress in nucleic acid research and molecular biology},
A number of laboratories have shown that those types of DNA damage that are generally reparable by base excision repair are efficiently repaired in mtDNA. In contrast, most types of damage that require other sorts of repair machinery are not effectively repaired in mtDNA. We have shown that a set of highly purified mitochondrial proteins, including AP endonuclease (APE), DNA polymerase gamma, and mtDNA ligase, is capable of efficiently repairing abasic (AP) sites in mtDNA. These three enzymes… CONTINUE READING
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