Enzymological basis for growth inhibition by L-phenylalanine in the cyanobacterium Synechocystis sp. 29108.

@article{Hall1980EnzymologicalBF,
  title={Enzymological basis for growth inhibition by L-phenylalanine in the cyanobacterium Synechocystis sp. 29108.},
  author={Gordon C Nagayama Hall and Roy A. Jensen},
  journal={Journal of bacteriology},
  year={1980},
  volume={144 3},
  pages={1034-42}
}
The pattern of allosteric control in the biosynthetic pathway for aromatic amino acids provides a basis to explain vulnerability to growth inhibition by l-phenylalanine (0.2 mM or greater) in the unicellular cyanobacterium Synechocystis sp. 29108. We attribute growth inhibition to the hypersensitivity of 3-deoxy-d-arabinoheptulosonate 7-phosphate synthase to feedback inhibition by l-phenylalanine. Hyperregulation of this initial enzyme of aromatic biosynthesis depletes the supply of precursors… CONTINUE READING

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