Enzymic preparation of water-soluble chitosan and their antitumor activity.

  title={Enzymic preparation of water-soluble chitosan and their antitumor activity.},
  author={Caiqin Qin and Yumin Du and Ling Xiao and Zhan Li and Xiaohai Gao},
  journal={International journal of biological macromolecules},
  volume={31 1-3},
Water-soluble low-molecular-weight (LMW) chitosan was prepared from enzymatic hydrolysis with efficient hemicellulase. The hydrolysates were separated by ultrafiltration membranes. A separated fraction with Mw more than 5x10(3) and with a degree of deacetylation of 58% was water-soluble in the free amine form. The intraperitoneal injection of LMW chitosan and its N-acetyl product inhibited the growth of sacroma 180 (S180) tumor cells in the mice, and the maximum inhibitory rate reached 64.2… CONTINUE READING


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