Enzymic imbalance in serine metabolism in rat hepatomas.

@article{Snell1986EnzymicII,
  title={Enzymic imbalance in serine metabolism in rat hepatomas.},
  author={Keith D.M. Snell and George Russell Weber},
  journal={The Biochemical journal},
  year={1986},
  volume={233 2},
  pages={
          617-20
        }
}
The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells. 

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