Enzymes without borders: mobilizing substrates, delivering products.

@article{Forneris2008EnzymesWB,
  title={Enzymes without borders: mobilizing substrates, delivering products.},
  author={Federico Forneris and Andrea Mattevi},
  journal={Science},
  year={2008},
  volume={321 5886},
  pages={213-6}
}
Many cellular reactions involve both hydrophobic and hydrophilic molecules that reside within the chemically distinct environments defined by the phospholipid-based membranes and the aqueous lumens of cytoplasm and organelles. Enzymes performing this type of reaction are required to access a lipophilic substrate located in the membranes and to catalyze its… CONTINUE READING