Enzymes that catalyse SN2 reaction mechanisms.

  title={Enzymes that catalyse SN2 reaction mechanisms.},
  author={David O'Hagan and Jason W. Schmidberger},
  journal={Natural product reports},
  volume={27 6},
Enzymes have evolved to catalyse reactions, reducing the activation barrier by lowering transition state energy. Many reaction types are represented in enzymology; however, it is noticeable that SN2-type nucleophilic reactions at carbon are not common. The activation barrier of an SN2 reaction is generally high, as it progresses through a trigonal… CONTINUE READING