Enzymes or redox couples? The kinetics of thioredoxin and glutaredoxin reactions in a systems biology context.

@article{Pillay2009EnzymesOR,
  title={Enzymes or redox couples? The kinetics of thioredoxin and glutaredoxin reactions in a systems biology context.},
  author={Ch{\'e} S. Pillay and Jan-Hendrik S. Hofmeyr and Brett G. Olivier and Jacky L. Snoep and Johann M. Rohwer},
  journal={The Biochemical journal},
  year={2009},
  volume={417 1},
  pages={269-75}
}
Systems biology approaches, such as kinetic modelling, could provide valuable insights into how thioredoxins, glutaredoxins and peroxiredoxins (here collectively called redoxins), and the systems that reduce these molecules are regulated. However, it is not clear whether redoxins should be described as redox couples (with redox potentials) or as enzymes (with Michaelis-Menten parameters) in such approaches. We show that in complete redoxin systems, redoxin substrate saturation and other… CONTINUE READING
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