• Corpus ID: 14883134

Enzymes of uracil catabolism in normal and neoplastic human tissues.

@article{Naguib1985EnzymesOU,
  title={Enzymes of uracil catabolism in normal and neoplastic human tissues.},
  author={Fardos N. M. Naguib and Mahmoud H. el Kouni and Sungman Cha},
  journal={Cancer research},
  year={1985},
  volume={45 11 Pt 1},
  pages={
          5405-12
        }
}
Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta-ureidopropionase (EC 3.5.1.6) were compared in the cytosolic extract of several normal and neoplastic human tissues. The activity was measured by following the catabolism of [6-14C]-uracil to dihydrouracil, carbamyl-beta-alanine, and beta-alanine. Substrate inhibition, hysteresis, allosterism, and the lack of dihydropyrimidinase are pointed out as special problems in… 

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