Enzymes involved in the bioconversion of ester-based prodrugs.

  title={Enzymes involved in the bioconversion of ester-based prodrugs.},
  author={Bianca M. Liederer and Ronald T. Borchardt},
  journal={Journal of pharmaceutical sciences},
  volume={95 6},
Enzymes are essential for the activation of many prodrugs. In this review, the most important enzymes (e.g., paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) involved in the bioconversion of ester-based prodrugs will be discussed in terms of their biology and biochemistry. Most of these enzymes fall into the category of hydrolytic enzymes. However, nonhydrolytic enzymes, including cytochrome P450s, can also catalyze the bioconversion of ester prodrugs and thus will be… CONTINUE READING

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