Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism

@inproceedings{Shimmura2013EnzymesIT,
  title={Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism},
  author={Chie Shimmura and Katsuaki Suzuki and Yasuhide Iwata and Kenji Tsuchiya and Kenji Ohno and Hideo Matsuzaki and Katsuya Iwata and Yosuke Kameno and Taro Takahashi and Tomoyasu Wakuda and Kazutoshi Nakamura and Kenji Hashimoto and Norio Mori},
  booktitle={Molecular Autism},
  year={2013}
}
BackgroundAccumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamatergic neurotransmission. We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism.MethodsWe performed Western blot analyses for the protein expression levels of enzymes in the glutamate-glutamine cycle… CONTINUE READING
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