Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦

@article{Wada2007EnzymesAR,
  title={Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦},
  author={Masayuki Wada and Cynthia J. DeLong and Yu H. Hong and Caroline Jill Rieke and Inseok Song and Ranjinder S. Sidhu and C S Yuan and Mark Warnock and Alvin H. Schmaier and Chieko Yokoyama and Emer M. Smyth and Stephen J. Wilson and Garret A. FitzGerald and R. Michael Garavito and Dexin Sui and John W. Regan and William L. Smith},
  journal={Journal of Biological Chemistry},
  year={2007},
  volume={282},
  pages={22254 - 22266}
}
Dietary fish oil containing ω3 highly unsaturated fatty acids has cardioprotective and anti-inflammatory effects. Prostaglandins (PGs) and thromboxanes are produced in vivo both from the ω6 fatty acid arachidonic acid (AA) and the ω3 fatty acid eicosapentaenoic acid (EPA). Certain beneficial effects of fish oil may result from altered PG metabolism resulting from increases in the EPA/AA ratios of precursor phospholipids. Here we report in vitro specificities of prostanoid enzymes and receptors… Expand
Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids*
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TLDR
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The currently available data suggest that some of the vasculo- and cardioprotective effects attributed to dietary n-3 PUFAs may be mediated by CYP-dependent metabolites of EPA and DHA. Expand
Cytochrome P 450-dependent metabolism of-6 and-3 long-chain polyunsaturated fatty acids
Dietary fish oil -3 fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using largely unknown mechanisms.Expand
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TLDR
It seems that the overall consequences of CYP activation largely depend on enzyme substrate preference and the endogenous ω-3/ω-6 PUFA ratio. Expand
Formation of Highly Reactive Cyclopentenone Isoprostane Compounds (A3/J3-Isoprostanes) in Vivo from Eicosapentaenoic Acid*
TLDR
These studies have, for the first time, definitively characterized novel, highly reactive A/J-ring IsoP compounds that form in abundance from the oxidation of EPA in vivo. Expand
The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling.
  • I. Fleming
  • Biology, Medicine
  • Vascular pharmacology
  • 2016
TLDR
The evidence for a physiological role for EETs in the regulation of vascular homeostasis is outlined and it seems that the overall consequences of CYP epoxygenase activation largely depend on enzyme substrate preference and the endogenous Ω-3/Ω-6 PUFA ratio. Expand
Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells.
TLDR
It is concluded that EPA-FFA drives a COX-2-dependent "PGE (2)-to-PGE(3) switch" in human CRC cells and that PGE (3) acts as a partial agonist at the PGE(2) EP4 receptor. Expand
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TLDR
In resident peritoneal macrophages, docosapentaenoic acid (DPA) was responsible for cyclooxygenase inhibition after EPA supplementation, offering fresh insights into how EPA exerts anti-inflammatory effects indirectly through elongation to 22-carbon DPA. Expand
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