Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps.

  title={Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps.},
  author={Eric Metzen},
  journal={The Biochemical journal},
  volume={408 2},
The transcriptional activator HIF (hypoxia-inducible factor) is a focal point of biomedical research because many situations in physiology and in pathology coincide with hypoxia. The effects of HIF activation may be a facet of normal growth, as in embryonic development, they may counterbalance a disease, as seen in the stimulation of erythropoiesis in anaemia, and they may be part of the pathological processes, as exemplified by tumour angiogenesis. The oxygen-sensitive alpha-subunits of HIF… CONTINUE READING
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protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

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