Enzyme-specific differences in mannose phosphorylation between GlcNAc-1-phosphotransferase αβ and γ subunit deficient zebrafish support cathepsin proteases as early mediators of mucolipidosis pathology.

@article{FlanaganSteet2016EnzymespecificDI,
  title={Enzyme-specific differences in mannose phosphorylation between GlcNAc-1-phosphotransferase αβ and γ subunit deficient zebrafish support cathepsin proteases as early mediators of mucolipidosis pathology.},
  author={Heather R. Flanagan-Steet and Courtney Matheny and Aaron C. Petrey and Joshua D Parker and Richard A Steet},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1860 9},
  pages={1845-53}
}
Targeting soluble acid hydrolases to lysosomes requires the addition of mannose 6-phosphate residues on their N-glycans. This process is initiated by GlcNAc-1-phosphotransferase, a multi-subunit enzyme encoded by the GNPTAB and GNPTG genes. The GNPTAB gene products (the α and ß subunits) are responsible for recognition and catalysis of hydrolases whereas the GNPTG gene product (the γ subunit) enhances mannose phosphorylation of a subset of hydrolases. Here we identify and characterize a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
0 Citations
44 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 44 references

M

  • A. C. Petrey, H. Flanagan-Steet, S. Johnson, X. Fan
  • De la Rosa, M.E. Haskins, A.V. Nairn, K.W…
  • 2012
Highly Influential
9 Excerpts

E

  • Y. Qian
  • van Meel, H. Flanagan-Steet, A. Yox, R. Steet, S…
  • 2015

D

  • J. G. Leroy
  • Sillence, T.Wood, J. Barnes, R.R. Lebel, M.J…
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…