Enzyme promiscuity: a mechanistic and evolutionary perspective.

  title={Enzyme promiscuity: a mechanistic and evolutionary perspective.},
  author={Olga Khersonsky and Dan S. Tawfik},
  journal={Annual review of biochemistry},
Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other than those for which they evolved. Here, we discuss the structural, mechanistic, and evolutionary implications of this manifestation of infidelity of molecular recognition. We define promiscuity and related phenomena and also address their generality and physiological implications. We discuss the mechanistic enzymology of promiscuity--how enzymes, which generally exert exquisite specificity, catalyze… CONTINUE READING
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