Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels.

@article{Lee2011EnzymemediatedCO,
  title={Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels.},
  author={Soo Hyeon Lee and Yuhan Lee and Sang-Woo Lee and Ha-Yeun Ji and Ji-Hee Lee and Doo Sung Lee and Tae Gwan Park},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 4},
  pages={
          1468-76
        }
}
A new class of injectable and erodible hydrogels exhibiting highly robust gel strength at body temperature was fabricated by enzyme-mediated cross-linking between Pluronic copolymer micelles. Tyramine-conjugated Pluronic F-127 tri-block copolymers at two terminal ends of polyethylene oxide (PEO) side chains were synthesized and utilized to form self-assembled micelles in aqueous solution. Tyrosinase was employed to convert tyramine-conjugated micelles to highly reactive catechol conjugated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Hydrogels with Micellar Hydrophobic (Nano)Domains

  • Front. Mater.
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED